| Autor: |
Hideaki Shiraishi, Kiyoshi Egawa, Tomoshiro Ito, Osamu Kawano, Naoko Asahina, Shinobu Kohsaka |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Epilepsy and Behavior Case Reports, Vol 8, Iss C, Pp 44-46 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2213-3232 |
| DOI: |
10.1016/j.ebcr.2017.05.004 |
| Popis: |
We administered perampanel (PER) to a bedridden 13-year-old male patient with dentatorubral-pallidoluysian atrophy (DRPLA). The DRPLA diagnosis was based on the presence of a CAG trinucleotide repeat in the ATN1 gene. The patient experienced continuous myoclonic seizures and weekly generalized tonic–clonic seizures (GTCs). PER stopped the patient's myoclonic seizures and reduced the GTCs to fragmented clonic seizures. The patient recovered his intellectual abilities and began to walk again with assistance. We suggest that PER be considered as one of the key drugs used to treat patients with DRPLA. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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