Associations of circulating biomarkers with the presence and severity of coronary, carotid and femoral arterial atherosclerosis
| Autor: | V. A. Metelskaya, M. V. Zhatkina, N. E. Gavrilova, E. B. Yarovaya, N. L. Bogdanova, V. A. Kutsenko, B. A. Rudenko, O. M. Drapkina |
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| Jazyk: | ruština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Кардиоваскулярная терапия и профилактика, Vol 20, Iss 8 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1728-8800 2619-0125 |
| DOI: | 10.15829/1728-8800-2021-3098 |
| Popis: | Aim. To identify and characterize the associations of the presence and severity of atherosclerosis of various localization with the blood level of biochemical parameters, as well as to assess the potential of their use as markers of metabolic disorders with increased atherogenic potential.Material and methods. The study included 216 patients (men, 53%) aged 24-87 years (mean age, 61,5±10,73 years). All patients underwent coronary angiography, carotid (CA) and femoral arterial (FA) duplex ultrasound to assess the presence and severity of atherosclerosis. In blood serum/plasma, biochemical parameters were analyzed using standard methods.Results. Based on the analysis of circulating biomarker profile, diagnostic complexes have been established that allow assessing atherosclerosis of different localization. According to the data obtained, the determinants of coronary and CA atherosclerosis are endothelial dysfunction (concentration of nitric oxide metabolites |
| Databáze: | Directory of Open Access Journals |
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