| Autor: |
Khaled A. Nematallah, Nahla A. Ayoub, Essam Abdelsattar, Meselhy R. Meselhy, Mohey M. Elmazar, Ahmed H. El-Khatib, Michael W. Linscheid, Rania M. Hathout, Kavitha Godugu, Aya Adel, Shaker A. Mousa |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 49, Iss , Pp 401-411 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2018.08.032 |
| Popis: |
Ajwa fruits are among the most nutritious and economically valuable fruits. In this study, the effect of different solvents on the extraction of polyphenols was investigated. Aqueous acetone (50%) extract contained the highest content of polyphenols and flavonoids. Filtration of the extract through a Diaion HP-20 column led to a polyphenols-enriched fraction (Fr 1) that had the highest antioxidant activity as measured with ORAC and DPPH assays. Metabolic profiling of the different extracts using HPLC-ESI-QTOF-MS-MS led to the tentative identification of 33 secondary metabolites: 3 phenolic acids, 19 flavonoid glycosides including 4 sulfated derivatives, 2 lignans, and 9 fatty acids. Fr 1 showed a promising hepatoprotective activity when tested in-vitro utilizing HepG2 cell lines and in-vivo against thioacetamide-induced liver fibrosis in mice. Ingestion of Fr 1 in the form of a microemulsion had significantly higher oral bioavailability than when ingested as a suspension in water. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect