| Autor: |
Hannah Hussey, Mary-Ann Davies, Alexa Heekes, Carolyn Williamson, Ziyaad Valley-Omar, Diana Hardie, Stephen Korsman, Deelan Doolabh, Wolfgang Preiser, Tongai Maponga, Arash Iranzadeh, Sean Wasserman, Linda Boloko, Greg Symons, Peter Raubenheimer, Arifa Parker, Neshaad Schrueder, Wesley Solomon, Petro Rousseau, Nicole Wolter, Waasila Jassat, Cheryl Cohen, Richard Lessells, Robert J Wilkinson, Andrew Boulle, Nei-yuan Hsiao |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 118, Iss , Pp 150-154 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2022.02.051 |
| Popis: |
Background: At present, it is unclear whether the extent of reduced risk of severe disease seen with SARS-Cov-2 Omicron variant infection is caused by a decrease in variant virulence or by higher levels of population immunity. Methods: RdRp target delay (RTD) in the Seegene AllplexTM 2019-nCoV PCR assay is a proxy marker for the Delta variant. The absence of this proxy marker in the transition period was used to identify suspected Omicron infections.Cox regression was performed for the outcome of hospital admission in those who tested positive for SARS-CoV-2 on the Seegene AllplexTM assay from November 1 to December 14, 2021 in the Western Cape Province, South Africa, in the public sector. Adjustments were made for vaccination status and prior diagnosis of infection. Results: A total of 150 cases with RTD and 1486 cases without RTD were included. Cases without RTD had a lower hazard of admission (adjusted hazard ratio [aHR], 0.56; 95% confidence interval [CI], 0.34-0.91). Complete vaccination was protective against admission, with an aHR of 0.45 (95% CI, 0.26-0.77). Conclusion: Omicron has resulted in a lower risk of hospital admission compared with contemporaneous Delta infection, when using the proxy marker of RTD. Under-ascertainment of reinfections with an immune escape variant remains a challenge to accurately assessing variant virulence. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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