| Autor: |
C. Marin, M. Bonastre, G. Mengod, R. Cortés, A. Giralt, J.A. Obeso, A.H. Schapira |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Neurobiology of Disease, Vol 64, Iss , Pp 36-47 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1095-953X |
| DOI: |
10.1016/j.nbd.2013.12.009 |
| Popis: |
The most appropriate time for the initiation of dopaminergic symptomatic therapy in Parkinson's disease remains debatable. It has been suggested that early correction of basal ganglia pathophysiological abnormalities may have long-term beneficial effects. To test this hypothesis, we investigated the early and delayed actions of L-dopa and pramipexole, using a delayed-start protocol of treatment. The effects of early and delayed administration of these drugs on motor response, development of dyskinesias, neurogenesis and molecular markers in basal ganglia were studied in rats with a unilateral and partial 6-hydroxydopamine-induced nigrostriatal lesion. Ten days after lesioning, rats received treatment with: a) L-dopa methyl ester (25 mg/kg with 6.25 mg/kg of benserazide, i.p., twice a day); b) pramipexole (0.5 mg/kg, sc, twice a day) or c) saline for 4 weeks. Four weeks after treatment initiation, rats from the saline group were distributed in three groups that then received the following treatments: d) L-dopa, e) pramipexole or f) saline, for 4 weeks more. Three animals in each treatment arm received 5-bromo-2-deoxyuridine injections (200 mg/kg) 3 days before starting treatment. When compared with delayed-start L-dopa, early-start L-dopa treatment induced a lower rotational response (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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