A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion

Autor: Ka Man Carmen Chan, Sungmin Son, Eva M Schmid, Daniel A Fletcher
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: eLife, Vol 9 (2020)
Druh dokumentu: article
ISSN: 2050-084X
DOI: 10.7554/eLife.51358
Popis: Cell-cell fusion, which is essential for tissue development and used by some viruses to form pathological syncytia, is typically driven by fusogenic membrane proteins with tall (>10 nm) ectodomains that undergo conformational changes to bring apposing membranes in close contact prior to fusion. Here we report that a viral fusogen with a short (
Databáze: Directory of Open Access Journals