Autor: |
Sean M. Davidson, Jaime A. Riquelme, Ying Zheng, Jose M. Vicencio, Sergio Lavandero, Derek M. Yellon |
Jazyk: |
angličtina |
Rok vydání: |
2018 |
Předmět: |
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Zdroj: |
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) |
Druh dokumentu: |
article |
ISSN: |
2045-2322 |
DOI: |
10.1038/s41598-018-34357-z |
Popis: |
Abstract Extracellular vesicles (EVs) such as exosomes are nano-sized vesicles that carry proteins and miRNAs and can transmit signals between cells. We hypothesized that exosomes from endothelial cells can transmit protective signals to cardiomyocytes. Co-culture of primary adult rat cardiomyocytes with normoxic HUVEC cells separated by a cell-impermeable membrane reduced the percentage of cardiomyocyte death following simulated ischaemia and reperfusion (sIR) from 80 ± 11% to 51 ± 4% (P |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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