Synthesis, Anti-inflammatory and Antioxidant Activities of Novel 3H-Thiazolo[4,5-b]pyridines

Autor:	Taras I. Chaban, Volodymyr V. Ogurtsov, Vasyl S. Matiychuk, Ihor G. Chaban, Inna L. Demchuk, Ihor A. Nektegayev
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	thiazolo[4 5-b]pyridines synthesis anti-inflammatory activity antioxidant activity Chemistry QD1-999
Zdroj:	Acta Chimica Slovenica, Vol 66, Iss 1, Pp 103-111 (2019)
Druh dokumentu:	article
ISSN:	1318-0207 1580-3155
DOI:	10.17344/acsi.2018.4570
Popis:	5-Hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one was obtained by the reaction of 4-iminothiazolidin-2-one with acetoacetic ester. Further structural modifications include the introduction of diversity at the C5 and C6 positions. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan-induced rat paw edema method. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0e1d5494b20e4716a19983c7f8924ede Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF