Weight-loss interventions and levonorgestrel intrauterine system implantation for early-stage endometrial cancer and atypical endometrial hyperplasia to reduce perioperative risk of severely obese patients

Autor: Roze Isono-Taniguchi, Hiroshi Tsubamoto, Kayo Inoue, Tomoko Ueda, Shinichiro Saeki, Yumi Takimoto, Yu Wakimoto, Hiroaki Shibahara
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Gynecology and Minimally Invasive Therapy, Vol 12, Iss 3, Pp 175-178 (2023)
Druh dokumentu: article
ISSN: 2213-3070
DOI: 10.4103/gmit.gmit_98_22
Popis: Endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) are associated with obesity, which increases the perioperative morbidity and surgical difficulties in laparoscopic and robotic surgery. Weight-loss interventions (WLIs) are likely to reduce morbidity; however, delayed surgery may cause cancer progression. To minimize the tumor progression, levonorgestrel intrauterine system (LNG-IUS) with minimal side effects was used until the planned surgery. During 2016 and 2021, we conducted preoperative management of WLI using LNG-IUS for seven highly obese women with a body mass index (BMI) ≥35 kg/m2 who had AEH and EC with Grade 1 and no myometrial invasion on magnetic resonance imaging. In three of the seven patients, the BMI decreased by more than 5. Two patients with AEH achieved remission after LNG-IUS placement and requested conservative management. Five patients with EC underwent laparoscopic hysterectomy, without perioperative complications.
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