High‐throughput screening and biological display technology: Applications in molecular imaging

Autor:	Renli Luo, Hongguang Liu, Zhen Cheng
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	molecular imaging high‐throughput screening ligand selection phage display yeast display ribosome display Medical physics. Medical radiology. Nuclear medicine R895-920
Zdroj:	iRADIOLOGY, Vol 1, Iss 1, Pp 18-35 (2023)
Druh dokumentu:	article
ISSN:	2834-2879 2834-2860
DOI:	10.1002/ird3.11
Popis:	Abstract Molecular imaging plays important roles in many fields, including disease diagnosis, therapeutic efficacy evaluation, intraoperative imaging guidance, drug metabolism monitoring, and patient selection for appropriate treatment. As a key component, the targeting ligand determines the specificity, affinity, and in vivo performance of molecular imaging probes. In this review, high‐throughput screening and biological display platforms for the discovery of ligands applicable to molecular imaging are briefly reviewed. Basic information on ligand development for molecular imaging is first introduced, followed by a presentation of various selection platforms and typical or iterative cases. The features, advantages, limitations, and application scope of screening and display platforms are compared and discussed. Last, a basic selection strategy and a perspective for protein‐based ligands are provided.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0c613149d0b242b3a42b7488f53d669e Zobrazit plný text záznamu Plný text View record in DOAJ