| Autor: |
Li Li Ji, Jonathan R. Dickman, Chounghun Kang, Ryan Koenig |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Dose-Response, Vol 8 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1559-3258 |
| DOI: |
10.2203/dose-response.09-048.Ji |
| Popis: |
Hormesis plays a critical role in producing some major benefits derived from physical exercise. However whether these known cellular mechanisms are applicable to ameliorate age-related deterioration of muscle function is not entirely clear. The present communication proposes that antioxidant adaptation, the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α activated mitochondrial biogenesis, and eccentric contraction-induced, cytokine-propelled muscle inflammation could be important redox-sensitive pathways by which exercise-induced disturbance in oxidant-antioxidant hemeostasis may serve as a heretic stimulus to promote adaptations that help healthy aging and improve the quality of life. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
