| Autor: |
Mevlüt DOĞUKAN, Murat BIÇAKCIOĞLU, Mehmet DURAN, Zümrüt DOĞAN, Bilge AYDIN TÜRK, Öznur ULUDAĞ |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Kafkas Universitesi Veteriner Fakültesi Dergisi, Vol 27, Iss 6, Pp 699-706 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1309-2251 |
| DOI: |
10.9775/kvfd.2021.26135 |
| Popis: |
Septicemia caused by Gram-negative bacteria is an infection associated with liver dysfunction. Quercetin is a natural flavonoid found in vegetables and fruits and has anti-inflammatory, antioxidant, cytoprotective and antiallergic properties. This research aims to investigate the effects of quercetin on the liver against tissue damage due to sepsis-induced oxidative stress. Thirty-two male rats were used in the study. The animals were randomly divided into 5 groups. Quercetin was dissolved in 20 mg/kg of olive oil daily for 15 days and given through oral gavage. The cecal-ligation sepsis model was applied to the group 3 and group 4. In histopathological evaluation; inflammation involving moderate neutrophils and lymphocytes was observed in most portal areas in the group where sepsis was created (Group 3). In the sepsis group administered quercetin (Group 4) only a few portal areas had a milder inflammation with fewer neutrophils than the sepsis group. There was a significant difference between group 3, 4, and all other groups in ALT and AST values. A significant difference was observed between group 3, 4 and other groups in terms of tissue MDA, GSH levels. It was concluded that quercetin, a powerful antioxidant, can reduce liver damage caused by sepsis and has the potential to be used to help treat sepsis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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