Nicolau syndrome following glatiramer acetate for multiple sclerosis: Case and review of reports

Autor:	Methma Udawatta, Farrah J. Mateen
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Annals of Clinical and Translational Neurology, Vol 11, Iss 4, Pp 1080-1085 (2024)
Druh dokumentu:	article
ISSN:	2328-9503
DOI:	10.1002/acn3.52044
Popis:	Abstract Nicolau syndrome is a rare, iatrogenic skin reaction after parental drug administration, characterized by severe pain at an injection site, followed by hemorrhage, ulceration, and often necrosis. We present a case of a patient on glatiramer acetate for many years (initially Copaxone then Glatopa) who developed Nicolau syndrome, the second reported case after generic glatiramer acetate. All reported cases of Nicolau syndrome after glatiramer acetate are reviewed. The case highlights the importance of prompt recognition of this skin reaction by neurologists and raises awareness of the risks of skin reactions even in low‐risk injectable DMTs.
Databáze:	Directory of Open Access Journals
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