Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study.

Autor: Euclides Nenga Manuel Sacomboio, Cruz Dos Santos Sebastião, Silvana Teresa da Costa Salvador, Joaquim António João, Daisy Viviana Sebastião Bapolo, Ngiambudulu M Francisco, Joana Morais, Eduardo Ekundi Valentim
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: PLoS ONE, Vol 17, Iss 5, p e0267671 (2022)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0267671
Popis: BackgroundDespite the guidelines provided by the World Health Organization for the treatment of malaria, treatment failure occurs in many hospitalized patients.ObjectiveEvaluate whether blood cell count parameters may serve as predictors for malaria treatment.MethodologyA cross-sectional study with a quantitative approach.ResultsOf the 219 patients, 21.5% showed failure to antimalarial treatment, Patient with 21 and 40 years (72.6%), male (53.4%), from peri-urban area (47.5%), with high parasitemia (59.8%), treated with Arthemeter (90.9%) and the mortality were 5.9%. Significant associations were observed between occupation, level of parasitemia and outcome with resistance to antimalarial treatment (pConclusionThe importance of blood cell count parameters in monitoring malaria therapy necessitates the urgent need to re-evaluate Artemether-based therapy. Future studies involving more participants in different settings are needed to provide further evidence.
Databáze: Directory of Open Access Journals
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