Proteomic Analysis of the Alterations in Follicular Fluid Proteins During Oocyte Maturation in Humans

Autor: Chong Wang, Xiaoyang Fei, Hongyan Zhang, Wenjing Zhou, Zhaojun Cheng, Ying Feng
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Endocrinology, Vol 12 (2022)
Druh dokumentu: article
ISSN: 1664-2392
DOI: 10.3389/fendo.2021.830691
Popis: Many components in ovarian follicles (follicular fluid, cumulus cells, granular cells, etc.) dynamically change during folliculogenesis and play a positive or negative role in oocyte maturation. Infertile women who underwent intracytoplasmic sperm injection (ICSI) treatment in the reproductive medicine centre of Hangzhou Women’s Hospital between October 2018 and October 2021 were included. The ovarian follicular fluid and cumulus cells of diminished ovarian response (DOR) patients and control subjects with medical records of clinical data were collected. In total, 31 differentially expressed proteins, including 10 upregulated proteins (>1.50-fold, P
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