Protective Effect of Hydroalcoholic Extract Tribulus terrestris on Cisplatin Cytotoxicity on Sperm Viability and Count in Mice
| Autor: | Z Keshtmand, Sh Oryan, A Ghanbari, M Khazaee |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Journal of Medicinal Plants, Vol 13, Iss 52, Pp 66-72 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2717-204X 2717-2058 |
| Popis: | Background: Cisplatin is an anti-cancer drug used in chemotherapy. The side effects of this drug include anoretic, nausea, decrease in genital gland function, azoospermia and oligospermia. Tribulus terrestris has many compounds mostly, that caused antioxidant and protective properties. Objective: The purpose of the present study to investigate protective effect of hydro-alcoholic extract Tribulus terrestris on cisplatin cytotoxicity on sperm viability and count in mice. Methods: Cisplatin and Tribulus terrestris extract were given to 30 mice for a period of 4 days. The mice were weighted and after anesthesia, their epididymis was taken out and sperm viability and sperm count were investigated, Student t-test was applied for the statistical analysis. Results: The results show that cisplatin alone leads to a reduction in body and epididymis weight, and sperm count and sperm viability compared to the control group (p |
| Databáze: | Directory of Open Access Journals |
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