Structural basis of substrate recognition and thermal protection by a small heat shock protein

Autor: Chuanyang Yu, Stephen King Pong Leung, Wenxin Zhang, Louis Tung Faat Lai, Ying Ki Chan, Man Chit Wong, Samir Benlekbir, Yong Cui, Liwen Jiang, Wilson Chun Yu Lau
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-23338-y
Popis: Structural insights into the small heat shock proteins (sHsps) complexes with their substrates are sparse. Here, cryo-EM structure of a plastid sHsp, Hsp21, in complex with a bona fide substrate 1-deoxy-D-xylulose 5-phosphate synthase (DXPS), suggests the anti-aggregation mechanism employed by sHsps.
Databáze: Directory of Open Access Journals