| Autor: |
Nastasiia Artamonova, Mona Kafka, Laura Faiss, David Avetisyan, Ignacio Puche Sanz, Giulia La Bombarda, Gennaio Iacono, Fabio Zattoni, Eberhard Steiner, Caroline D’Elia, Armin Pycha, Michael Ladurner, Samed Jagodic, Giorgio Gandaglia, Isabel Heidegger |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
European Urology Open Science, Vol 69, Iss , Pp 105-111 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-1683 |
| DOI: |
10.1016/j.euros.2024.09.005 |
| Popis: |
Background and objective: Collagen biosynthesis is intricately involved in the development and progression of solid tumors. Renin-angiotensin system inhibitors (RASi) impede TGF-β-mediated collagen synthesis in tumors by hindering activation of the angiotensin receptor. Our aim was to investigate a potential association between RASi use and the aggressiveness of prostate cancer (PCa). Methods: We conducted a retrospective multicenter analysis for a cohort of 1250 patients with PCa who underwent radical prostatectomy (RP) between 1990 and 2023 in four European high-volume centers. The study cohort comprised 625 RASi-treated patients and 625 age-matched RASi-naïve patients. Data for various parameters were collected, including age at RP, body mass index (BMI), prostate volume, prostate-specific antigen (PSA), percentage of free PSA, Gleason score (GS) at biopsy and RP, TNM stage, and the rate of biochemical recurrence (BCR). Clinical parameters for patients with and without RASi treatment were documented. Differences between the groups were compared using a Mann-Whitney U test and χ2 tests. Survival analyses were performed using the Kaplan-Meier method. Key findings and limitations: As expected, the RASi group had higher BMI levels than the RASi-naïve group (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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