| Autor: |
Anne Raafs, Job Verdonschot, João Pedro Ferreira, Ping Wang, Timothy Collier, Michiel Henkens, Jens Björkman, Alessandro Boccanelli, Andrew L. Clark, Christian Delles, Javier Diez, Arantxa González, Nicolas Girerd, J. Wouter Jukema, Florence Pinet, Patrick Rossignol, Thomas Thum, Nicolas Vodovar, Rudolf A. deBoer, Vanessa vanEmpel, Jan A. Staessen, Mark Hazebroek, John Cleland, Faiez Zannad, Stephane Heymans |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
ESC Heart Failure, Vol 8, Iss 5, Pp 3512-3520 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2055-5822 |
| DOI: |
10.1002/ehf2.13476 |
| Popis: |
Abstract Aims Heart failure (HF) is common in both men and women, yet disease pathophysiology, presentation, and progression differ between sexes. Studies addressing whether biomarkers predict new onset HF sex‐specifically are scarce. This study therefore aims to test the sex‐specificity of 252 protein biomarkers for new‐onset HF. Methods and results A matched case–control design in patients selected from cohorts within the HOMAGE consortium was used. Cases (new‐onset HF, n = 562) and controls (n = 780) were matched for cohort (PREDICTOR, HEALTH‐ABC, & PROSPER), follow‐up time (defined as time from entry to incident HF), and age. Incident HF was defined as first hospitalization for HF. Targeted plasma proteins (n = 252) were measured using Proximity Extension Assay technology from O‐link. To look for sex differences for new onset HF, we adjusted for cohort, age, and baseline clinical parameters. At baseline, women had a biomarker profile reflecting activated metabolism and immune responses. However, none of the biomarkers had a significant interaction with sex in predicting new onset HF, but four biomarkers had a trend towards sex‐specificity (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text