Oxacillin-resistant Staphylococcus spp.: Impacts on fatality in a NICU in Brazil - confronting the perfect storm

Autor: Isadora Caixeta da Silveira Ferreira, Ralciane de Paula Menezes, Thiago Alves de Jesus, Mallu Santos Mendonça Lopes, Lúcio Borges de Araújo, Daniela Marques de Lima Mota Ferreira, Denise Von Dolinger de Brito Röder
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117373- (2024)
Druh dokumentu: article
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2024.117373
Popis: Objective: Analyse the incidence, risk factors, antimicrobial susceptibility profile, and fatality in neonates infected with oxacillin-resistant Staphylococcus spp. (ORS). Methods: In this retrospective observational descriptive cohort study, the medical records of neonates admitted to the Neonatal Intensive Care Unit (NICU) from January 2015 to June 2022 were analysed. Participants were monitored daily through the National Healthcare Safety Network. Results: Among the 1610 neonates, 193 (12 %) developed ORS infections, primarily in the bloodstream (96.8 %). The incidence of these infections/patient-days decreased by 51.8 % between 2016 (8.3) and 2022 (4). The median age of affected neonates was 17.5 days (IQR:12–28.7). Pre-emptive prescription of fourth-generation cephalosporins (OR=14.36; P
Databáze: Directory of Open Access Journals