Myocardial Infarction After High-Dose Catecholamine Application—A Case Report From an Experimental Imaging Study
| Autor: | Niklas Beyhoff, David Lohr, Arne Thiele, Anna Foryst-Ludwig, Robert Klopfleisch, Laura M. Schreiber, Ulrich Kintscher |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Frontiers in Cardiovascular Medicine, Vol 7 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2297-055X 90626672 |
| DOI: | 10.3389/fcvm.2020.580296 |
| Popis: | Although heart failure following myocardial infarction (MI) represents a major health burden, underlying microstructural and functional changes remain incompletely understood. Here, we report on a case of unexpected MI after treatment with the catecholamine isoproterenol in an experimental imaging study in mice using different state-of-the-art imaging modalities. The decline in cardiac function was documented by ultrahigh-frequency echocardiography and speckle-tracking analyses. Myocardial microstructure was studied ex vivo at a spatial resolution of 100 × 100 × 100 μm3 using diffusion tensor magnetic resonance imaging (DT-MRI) and histopathologic analyses. Two weeks after ISO treatment, the animal showed an apical aneurysm accompanied by reduced radial strain in corresponding segments and impaired global systolic function. DT-MRI revealed a loss of contractile fiber tracts together with a disarray of remaining fibers as corresponding microstructural correlates. This preclinical case report provides valuable insights into pathophysiology and morphologic–functional relations of heart failure following MI using emerging imaging technologies. |
| Databáze: | Directory of Open Access Journals |
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