Dynamic functional clot formation in patients undergoing endoscopic mucosal resection

Autor: Bernd Froessler, Leonardo Zorron Cheng Tao Pu, Natalie Aboustate, Amanda Ovenden, Rajvinder Singh
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: JGH Open, Vol 4, Iss 4, Pp 632-635 (2020)
Druh dokumentu: article
ISSN: 2397-9070
DOI: 10.1002/jgh3.12306
Popis: Background and Aim Electric burns can induce fibrinolytic activity. Endoscopic mucosal resection (EMR) is a minimally invasive technique utilizing electrocautery for resection of dysplastic lesions from the gastrointestinal tract. EMR's main complication is clinically significant postendoscopic bleeding. Currently, no studies have investigated the impact of electrocautery during EMR on the coagulation cascade by viscoelastic hemostatic assay. Methods Thrombelastometry was performed and plasminogen levels were measured on blood samples taken prior to EMR, within an hour following the procedure and 2 days post‐EMR. Data were natural log‐transformed and analyzed using repeated‐measure analysis of covariance (ANCOVA) accounting for age, sex, body mass index (BMI) and site of EMR. Results Plasminogen levels decreased post‐EMR (P = 0.001) and then increased 2 days post‐EMR (P
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