Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1
| Autor: | David W. Hogg, Andrea L. Reid, Thomas L. Dodsworth, Yani Chen, Ross M. Reid, Mei Xu, Mia Husic, Peggy R. Biga, Andrew Slee, Leslie T. Buck, Dalia Barsyte-Lovejoy, Marius Locke, David A. Lovejoy |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Frontiers in Physiology, Vol 13 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1664-042X 57640939 |
| DOI: | 10.3389/fphys.2022.1031264 |
| Popis: | Skeletal muscle regulation is responsible for voluntary muscular movement in vertebrates. The genes of two essential proteins, teneurins and latrophilins (LPHN), evolving in ancestors of multicellular animals form a ligand-receptor pair, and are now shown to be required for skeletal muscle function. Teneurins possess a bioactive peptide, termed the teneurin C-terminal associated peptide (TCAP) that interacts with the LPHNs to regulate skeletal muscle contractility strength and fatigue by an insulin-independent glucose importation mechanism in rats. CRISPR-based knockouts and siRNA-associated knockdowns of LPHN-1 and-3 in the C2C12 mouse skeletal cell line shows that TCAP stimulates an LPHN-dependent cytosolic Ca2+ signal transduction cascade to increase energy metabolism and enhance skeletal muscle function via increases in type-1 oxidative fiber formation and reduce the fatigue response. Thus, the teneurin/TCAP-LPHN system is presented as a novel mechanism that regulates the energy requirements and performance of skeletal muscle. |
| Databáze: | Directory of Open Access Journals |
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