Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection.
| Autor: | James W Kijas, Johannes A Lenstra, Ben Hayes, Simon Boitard, Laercio R Porto Neto, Magali San Cristobal, Bertrand Servin, Russell McCulloch, Vicki Whan, Kimberly Gietzen, Samuel Paiva, William Barendse, Elena Ciani, Herman Raadsma, John McEwan, Brian Dalrymple, International Sheep Genomics Consortium Members |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | PLoS Biology, Vol 10, Iss 2, p e1001258 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1544-9173 1545-7885 |
| DOI: | 10.1371/journal.pbio.1001258 |
| Popis: | Through their domestication and subsequent selection, sheep have been adapted to thrive in a diverse range of environments. To characterise the genetic consequence of both domestication and selection, we genotyped 49,034 SNP in 2,819 animals from a diverse collection of 74 sheep breeds. We find the majority of sheep populations contain high SNP diversity and have retained an effective population size much higher than most cattle or dog breeds, suggesting domestication occurred from a broad genetic base. Extensive haplotype sharing and generally low divergence time between breeds reveal frequent genetic exchange has occurred during the development of modern breeds. A scan of the genome for selection signals revealed 31 regions containing genes for coat pigmentation, skeletal morphology, body size, growth, and reproduction. We demonstrate the strongest selection signal has occurred in response to breeding for the absence of horns. The high density map of genetic variability provides an in-depth view of the genetic history for this important livestock species. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|