NucEnvDB: A Database of Nuclear Envelope Proteins and Their Interactions

Autor: Fotis A. Baltoumas, Dimitrios Sofras, Avgi E. Apostolakou, Zoi I. Litou, Vassiliki A. Iconomidou
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Membranes, Vol 13, Iss 1, p 62 (2023)
Druh dokumentu: article
ISSN: 2077-0375
DOI: 10.3390/membranes13010062
Popis: The nuclear envelope (NE) is a double-membrane system surrounding the nucleus of eukaryotic cells. A large number of proteins are localized in the NE, performing a wide variety of functions, from the bidirectional exchange of molecules between the cytoplasm and the nucleus to chromatin tethering, genome organization, regulation of signaling cascades, and many others. Despite its importance, several aspects of the NE, including its protein–protein interactions, remain understudied. In this work, we present NucEnvDB, a publicly available database of NE proteins and their interactions. Each database entry contains useful annotation including a description of its position in the NE, its interactions with other proteins, and cross-references to major biological repositories. In addition, the database provides users with a number of visualization and analysis tools, including the ability to construct and visualize protein–protein interaction networks and perform functional enrichment analysis for clusters of NE proteins and their interaction partners. The capabilities of NucEnvDB and its analysis tools are showcased by two informative case studies, exploring protein–protein interactions in Hutchinson–Gilford progeria and during SARS-CoV-2 infection at the level of the nuclear envelope.
Databáze: Directory of Open Access Journals
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