| Autor: |
Haihong Ge, Shuang Liu, Yan Cai, Zenghui Gao, Siyi Du, Zhiwei Miao, Guixian Xie |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
SynOpen, Vol 01, Iss 01, Pp 0068-0075 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2509-9396 |
| DOI: |
10.1055/s-0036-1590969 |
| Popis: |
Abstract The diastereospecific formation of β-amino-α-cyclopropenyl phosphonates has been achieved in moderate yields from the cyclopropenation of 1-alkynes with dialkyl α-diazophosphonates. The reaction was performed by using a combined catalyst consisting of Cu(MeCN)4BF4 and BF3·Et2O as additive in dichloromethane at 40 °C. A possible mechanism for the reaction has been proposed to explain the origin of the activation and the asymmetric induction. This method provides a versatile approach to β-amino-α-cyclopropenylphosphonates containing a quaternary stereogenic center with good efficiency and diastereoselectivity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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