Alterations of adiponectin gene expression and DNA methylation in adipose tissues and blood cells are associated with gestational diabetes and neonatal outcome

Autor: Raffael Ott, Jens H. Stupin, Kerstin Melchior, Karen Schellong, Thomas Ziska, Joachim W. Dudenhausen, Wolfgang Henrich, Rebecca C. Rancourt, Andreas Plagemann
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-12 (2018)
Druh dokumentu: article
ISSN: 1868-7075
1868-7083
DOI: 10.1186/s13148-018-0567-z
Popis: Abstract Background Adiponectin critically contributes to metabolic homeostasis, especially by insulin-sensitizing action. Gestational diabetes mellitus (GDM) is characterized by insulin resistance leading to materno-fetal hyperglycemia and detrimental birth outcomes. By investigating paired subcutaneous (SAT) and visceral adipose tissue (VAT) as well as blood (cell) samples of GDM-affected (n = 25) vs. matched control (n = 30) mother-child dyads of the prospective “EaCH” cohort study, we addressed whether alterations of adiponectin plasma, mRNA, and DNA methylation levels are associated with GDM and offspring characteristics. Results Hypoadiponectinemia was present in women with GDM, even after adjustment for body mass index (BMI). This was accompanied by significantly decreased mRNA levels in both SAT and VAT (P
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