Prognostic value of fibrinogen-to-albumin ratio combined with coronary calcification score in patients with suspected coronary artery disease

Autor: Xin-Xin Tian, Jun-Yi Luo, Fen Liu, Ya-Jing Qiu, Fan Luo, Lu Zeng, Zhuo-Ran Zhang, Yi-Ning Yang, Xiao-Mei Li
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 1471-2261
DOI: 10.1186/s12872-023-03193-z
Popis: Abstract Objective The aim of this work was to evaluate the predictive value of FAR combined with CACS for MACCEs. Background The fibrinogen-albumin-ratio (FAR), a novel biomarker of inflammation, is associated with the severity of coronary artery disease (CAD). Coronary calcification score (CACS) is associated with the severity of coronary stenosis and is closely related to the prognosis of CAD patients. What is the prognostic value of FAR in patients with chest pain, which has not been reported. This study aims to evaluate the relationship between CACS and FAR and their impact on prognosis in patients with suspected CAD. Methods We used information from 12,904 individuals who had coronary computed tomography angiography (CTA) for chest pain and tracked down any significant adverse cardiac and cerebrovascular events (MACCEs). The following formula was used to calculate FAR: fibrinogen (g/L)/albumin (g/L). Patients were separated into groups with greater levels of FAR (FAR-H) and lower levels of FAR (FAR-L) in accordance with the ideal cut-off value of FAR for MACCEs prediction. In addition, patients were divided into three groups based on their CACS scores (CACS ≤ 100, 100 400). Results 4946 patients [62(55–71) years, 64.4% male] were ultimately enrolled in the present study. During follow-up, a total of 234 cases (4.7%) of MACCEs were documented. Linear regression analysis results showed that CACS (R2 = 0.004, Standard β = 0.066, P
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