| Autor: |
A. M. Chudzinski-Tavassi, L. C. Carrijo-Carvalho |
| Jazyk: |
angličtina |
| Rok vydání: |
2006 |
| Předmět: |
|
| Zdroj: |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 2, Pp 159-171 (2006) |
| Druh dokumentu: |
article |
| ISSN: |
1678-9199 |
| DOI: |
10.1590/S1678-91992006000200002 |
| Popis: |
Lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of Brazil. Patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. A consumptive coagulopathy was found to be the main cause of bleeding complications observed in patients after contact with L. obliqua. Studies revealed that L. obliqua caterpillar bristle extract (LOCBE) displays a procoagulant activity that leads to intravascular thrombin formation, resulting in a special form of disseminated intravascular coagulation (DIC). Fibrinolysis seems to be secondary to the fibrin production, since no direct fibrinolytic activity was found in LOCBE. Two procoagulant toxins, a factor X activator (Losac) and a prothrombin activator (Lopap), were isolated from LOCBE and characterized. Infusion of Lopap into experimental animals triggered a condition similar to that observed in human envenomation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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