Doxycycline reduces liver and kidney injuries in a rat hemorrhagic shock model

Autor: Regina Sordi, Luana Bojko, Filipe R. M. B. Oliveira, Thiele Osvaldt Rosales, Camila Fernandes Souza, Lucas Wenceslau Moreno, Gustavo Ferreira Alves, José Carlos Rebuglio Vellosa, Daniel Fernandes, Jose Rosa Gomes
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-9 (2024)
Druh dokumentu: article
ISSN: 2197-425X
DOI: 10.1186/s40635-023-00586-4
Popis: Abstract Background Hemorrhagic shock (HS), which causes insufficient tissue perfusion, can result in multiple organ failure (MOF) and death. This study aimed to evaluate whether doxycycline (DOX) protects cardiovascular, kidney, and liver tissue from damage in a rat model of HS. Immediately before the resuscitation, DOX (10 mg/kg; i.v.) was administered, and its protective effects were assessed 24 h later. Mean arterial pressure, renal blood flow, heart rate, vasoactive drug response, and blood markers such as urea, creatinine, AST, ALT, CPK, CPR, and NOx levels were determined. Results We showed that DOX has a significant effect on renal blood flow and on urea, creatinine, AST, ALT, CPK, and NOx. Morphologically, DOX reduced the inflammatory process in the liver tissue. Conclusions We conclude that DOX protects the liver and kidney against injury and dysfunction in a HS model and could be a strategy to reduce organ damage associated with ischemia-and-reperfusion injury.
Databáze: Directory of Open Access Journals
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