Obesity, Inflammation and Neurological Alterations
| Autor: | E. Spinas, A. Saggini, S.K. Kritas, G. Cerulli, A. Caraffa, P. Antinolfi, A. Pantalone, A. Frydas, M. Tei, A. Speziali, R. Saggini, P. Conti |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | European Journal of Inflammation, Vol 12 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1721-727X 1721727X |
| DOI: | 10.1177/1721727X1401200302 |
| Popis: | Inflammation, neurodegeneration, imbalance of neurotransmitter systems, oxidative stress and depression are all risk factors for obesity. There is evidence regarding the cross-talk between adipose tissue and the immune system and obese patients may show an alteration of immune functions with major depression, including immune suppression with reduced T-cell and macrophage activity. Obesity is mediated by inflammatory cells such as lymphocytes, macrophages and mast cells which release pro-inflammatory cytokines and chemokines. Obesity-induced leukocyte infiltrations in adipose tissue cause cytokine/chemokine release and inflammation. Here, we report the relationship between obesity, neurological alterations and inflammation. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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