Droplet Digital PCR as a Molecular Tool for the Detection of the EGFR T790M Mutation in NSCLC Patients with the EGFR Activating Mutations

Autor:	Durgut S, Salihefendić L, Pećar D, Čeko I, Mulahuseinović N, Izmirlija M, Konjhodžić R
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	ddpcr liquid biopsy nsclc patients t790m Genetics QH426-470
Zdroj:	Balkan Journal of Medical Genetics, Vol 26, Iss 2, Pp 21-26 (2024)
Druh dokumentu:	article
ISSN:	2199-5761
DOI:	10.2478/bjmg-2023-0020
Popis:	Almost 50% of NSCLC patients who initially show a successful response to tyrosine kinase inhibitors targeted therapy (TKI therapy) eventually develop acquired EGFR T790M mutation. The T790M secondary mutation can cause resistance to the targeted therapy and disease relapse. Since this mutation can be present at very low frequencies in liquid biopsy samples, droplet digital PCR (ddPCR), due to its high sensitivity, has opened the possibility for minimally invasive monitoring of the disease during TKI targeted therapy.
Databáze:	Directory of Open Access Journals
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