Clinical and microbiological characteristics of non-tuberculous mycobacteria diseases in Singapore with a focus on pulmonary disease, 2012-2016

Autor:	Zoe Xiaozhu Zhang, Benjamin Pei Zhi Cherng, Li-Hwei Sng, Yen Ee Tan
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Non-tuberculous mycobacteria Mycobacterium abscessus Singapore Infectious and parasitic diseases RC109-216
Zdroj:	BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-8 (2019)
Druh dokumentu:	article
ISSN:	1471-2334
DOI:	10.1186/s12879-019-3909-3
Popis:	Abstract Background Information on non-tuberculosis mycobacterial (NTM) diseases remains limited in Singapore and other Southeast Asian countries. This study aimed to delineate epidemiological and clinical features of pulmonary NTM disease. Methods A retrospective review was performed on all NTM isolates identified in Singapore General Hospital from 2012 to 2016 using the 2007 ATS/IDSA diagnostic criteria. Results A total of 2026 NTM isolates from 852 patients were identified. M. abscessus-chelonae group (1010, 49.9%) was the most commonly isolated and implicated in pulmonary NTM disease. Pulmonary cases (352, 76%) had the highest prevalence among patients diagnosed with NTM diseases (465/852, 54.6%) with no gender difference. Male patients were older (68.5 years, P = 0.014) with a higher incidence of chronic obstructive pulmonary disease (COPD) (23.6%, P
Databáze:	Directory of Open Access Journals
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