Designing robust control-based HIV-treatment
| Autor: | Fredy Andrés Olarte Dussán, Carlos Arturo Clavijo Ramírez, Hernando Díaz Morales |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Ingeniería e Investigación, Vol 28, Iss 2, Pp 80-88 (2008) |
| Druh dokumentu: | article |
| ISSN: | 0120-5609 2248-8723 |
| Popis: | Designing a robust control-based treatment for human immunodeficiency virus (HIV)-infected patients was studied. The dynamics of the immune system’s response to infection was modelled using a 5th order nonlinear model with separate efficacy coefficients for protease inhibitor (PIs) and reverse transcriptase inhibitors (RTIs). The immune res-ponse has been represented as an uncertain system due to errors in parameter estimation and the existence of un-modelled dynamics. A polytopic system was constructed incorporating all possible system parameter values. A con-trol system was designed using robust pole location techniques stabilising the polytopic system around an equilibrium point having a low viral load. Numerical simulation results (including the organism’s pharmacokinetical response to anti-retroviral drugs) showed that the control law could lead to long-term stable conditions, even in extreme cases. |
| Databáze: | Directory of Open Access Journals |
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