| Autor: |
Felipe ten-Caten, Patrícia Gonzalez-Dias, Ícaro Castro, Rodrigo L.T. Ogava, Jeevan Giddaluru, Juan Carlo S. Silva, Felipe Martins, André N.A. Gonçalves, André G. Costa-Martins, José D. Araujo, Ana Carolina Viegas, Fernando Q. Cunha, Sandra Farsky, Fernando A. Bozza, Anna S. Levin, Pia S. Pannaraj, Thushan I. de Silva, Paola Minoprio, Fabiano Pinheiro da Silva, Bruno B. Andrade, Helder I. Nakaya |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 105, Iss , Pp 579-587 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2021.03.016 |
| Popis: |
Background: The progression and severity of COVID-19 vary significantly in the population. While the hallmarks of SARS-CoV-2 and severe COVID-19 within routine laboratory parameters are emerging, the impact of sex and age on these profiles is still unknown. Methods: A multidimensional analysis was performed involving millions of records of laboratory parameters and diagnostic tests for 178 887 individuals from Brazil, of whom 33 266 tested positive for SARS-CoV-2. Analyzed data included those relating to complete blood cell count, electrolytes, metabolites, arterial blood gases, enzymes, hormones, cancer biomarkers, and others. Findings: COVID-19 induced similar alterations in laboratory parameters in males and females. CRP and ferritin were increased, especially in older men with COVID-19, whereas abnormal liver function tests were common across several age groups, except for young women. Low peripheral blood basophils and eosinophils were more common in the elderly with COVID-19. Both male and female COVID-19 patients admitted to intensive care units displayed alterations in the coagulation system, and higher values for neutrophils, CRP, and lactate dehydrogenase. Conclusions: Our study uncovered the laboratory profiles of a large cohort of COVID-19 patients, which formed the basis of discrepancies influenced by aging and biological sex. These profiles directly linked COVID-19 disease presentation to an intricate interplay between sex, age, and immune activation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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