| Autor: |
Nina W. van der Hoeven, Gladys N. Janssens, Henk Everaars, Alexander Nap, Jorrit S. Lemkes, Guus A. de Waard, Peter M. van de Ven, Albert C. van Rossum, Javier Escaned, Hernan Mejia‐Renteria, Tim J. F. ten Cate, Jan J. Piek, Clemens von Birgelen, Marco Valgimigli, Roberto Diletti, Niels P. Riksen, Nicolas M. Van Mieghem, Robin Nijveldt, Maarten A. H. van Leeuwen, Niels van Royen |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 5 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.119.014411 |
| Popis: |
Background Off‐target properties of ticagrelor might reduce microvascular injury and improve clinical outcome in patients with ST‐segment–elevation myocardial infarction. The REDUCE‐MVI (Evaluation of Microvascular Injury in Revascularized Patients with ST‐Segment–Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel) trial reported no benefit of ticagrelor regarding microvascular function at 1 month. We now present the follow‐up data up to 1.5 years. Methods and Results We randomized 110 patients with ST‐segment–elevation myocardial infarction to either ticagrelor 90 mg twice daily or prasugrel 10 mg once a day. Platelet inhibition and peripheral endothelial function measurements including calculation of the reactive hyperemia index and clinical follow‐up were obtained up to 1.5 years. Major adverse clinical events and bleedings were scored. An intention to treat and a per‐protocol analysis were performed. There were no between‐group differences in platelet inhibition and endothelial function. At 1 year the reactive hyperemia index in the ticagrelor group was 0.66±0.26 versus 0.61±0.28 in the prasugrel group (P=0.31). Platelet inhibition was lower at 1 month versus 1 year in the total study population (61% [42%–81%] versus 83% [61%–95%]; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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