The function and architecture of DEAH/RHA helicases

Autor:	He Yangzi, Andersen Gregers R., Nielsen Klaus H.
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	deah/rha helicase pre-mrna splicing ribosome biogenesis rna binding site rna helicase a (rha) Biology (General) QH301-705.5
Zdroj:	Biomolecular Concepts, Vol 2, Iss 4, Pp 315-326 (2011)
Druh dokumentu:	article
ISSN:	1868-5021 1868-503X
DOI:	10.1515/bmc.2011.024
Popis:	Helicases are ubiquitous enzymes that participate in every aspect of nucleic acid metabolism. The DEAH/RHA family of helicases are involved in a variety of cellular processes including transcriptional and translational regulation, pre-mRNA splicing, pre-rRNA processing, mRNA export and decay, in addition to the innate immune response. Recently, the first crystal structures of a DEAH/RHA helicase unveiled the unique structural features of this helicase family. These structures furthermore illuminate the molecular mechanism of these proteins and provide a framework for analysis of their interaction with nucleic acids, regulatory proteins and large macromolecular complexes.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a01ca23db4ed4513874e03a0f1373007 Zobrazit plný text záznamu View record in DOAJ