| Autor: |
Deanne K. Thompson, Claire E. Kelly, Thijs Dhollander, Evelyne Muggli, Stephen Hearps, Sharon Lewis, Thi-Nhu-Ngoc Nguyen, Alicia Spittle, Elizabeth J. Elliott, Anthony Penington, Jane Halliday, Peter J. Anderson |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
NeuroImage: Clinical, Vol 42, Iss , Pp 103595- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2024.103595 |
| Popis: |
Background: The effects of low-moderate prenatal alcohol exposure (PAE) on brain development have been infrequently studied. Aim: To compare cortical and white matter structure between children aged 6 to 8 years with low-moderate PAE in trimester 1 only, low-moderate PAE throughout gestation, or no PAE. Methods: Women reported quantity and frequency of alcohol consumption before and during pregnancy. Magnetic resonance imaging was undertaken for 143 children aged 6 to 8 years with PAE during trimester 1 only (n = 44), PAE throughout gestation (n = 58), and no PAE (n = 41). T1-weighted images were processed using FreeSurfer, obtaining brain volume, area, and thickness of 34 cortical regions per hemisphere. Fibre density (FD), fibre cross-section (FC) and fibre density and cross-section (FDC) metrics were computed for diffusion images. Brain measures were compared between PAE groups adjusted for age and sex, then additionally for intracranial volume. Results: After adjustments, the right caudal anterior cingulate cortex volume (pFDR = 0.045) and area (pFDR = 0.008), and right cingulum tract cross-sectional area (pFWE |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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