Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens
| Autor: | Tutik Kusmiati, Ni Made Mertaniasih, Johanes Nugroho Eko Putranto, Budi Suprapti, Nadya Luthfah, Soedarsono Soedarsono, Winariani Koesoemoprodjo, Aryani Prawita Sari |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Acta Medica Indonesiana, Vol 54, Iss 1 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0125-9326 2338-2732 |
| Popis: | Background: Drug-resistant tuberculosis (DR-TB) is a global health concern. QTc prolongation is a serious adverse effect in DR-TB patients receiving a shorter regimen. This study aimed to evaluate the correlation of moxifloxacin concentration, CRP, and inflammatory cytokines with QTc interval in DR-TB patients treated with a shorter regimen. Methods: This study was performed in 2 groups of rifampicin-resistant (RR-TB) patients receiving shorter regimens. Correlation for all variables was analyzed. Results: CRP, IL-1β, and QTc baseline showed significant differences between 45 RR-TB patients on intensive phase and continuation phase with p-value of |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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