Curcumin-Loaded Chitosan/Gelatin Composite Sponge for Wound Healing Application

Autor: Van Cuong Nguyen, Van Boi Nguyen, Ming-Fa Hsieh
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: International Journal of Polymer Science, Vol 2013 (2013)
Druh dokumentu: article
ISSN: 1687-9422
1687-9430
DOI: 10.1155/2013/106570
Popis: Three composite sponges were made with 10% of curcumin and by using polymers, namely, chitosan and gelatin with various ratios. The chemical structure and morphology were evaluated by FTIR and SEM. These sponges were evaluated for water absorption capacity, antibacterial activity, in vitro drug release, and in vivo wound healing studies by excision wound model using rabbits. The in vivo study presented a greater wound closure in wounds treated with curcumin-composite sponge than those with composite sponge without curcumin and untreated group. These obtained results showed that combination of curcumin, chitosan and gelatin could improve the wound healing activity in comparison to chitosan, and gelatin without curcumin.
Databáze: Directory of Open Access Journals
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