Terapêutica combinada na diabetes mellitus não insulino-dependente.

Autor: F Ferreira, L G Sobrinho
Jazyk: English<br />Portuguese
Rok vydání: 1993
Předmět:
Zdroj: Acta Médica Portuguesa, Vol 6, Iss 6 (1993)
Druh dokumentu: article
ISSN: 0870-399X
1646-0758
DOI: 10.20344/amp.3087
Popis: In recent years an improved understanding of potential complications associated with hyperinsulinemia has led to a growing interest in alternatives to insulin monotherapy for patients with non-insulin-dependent diabetes mellitus, who have failed on a regimen of diet and sulphonylureas. These patients typically present normal or elevated levels of insulin. This problem which has been attributed to insulin resistance, is superimposed on the peripheral hyperinsulinemia resulting from subcutaneous insulin delivery. A plethora of clinical trials have reported on the efficacy of combining therapy in limiting insulin requirements while achieving better glycemic control. This paper attempts a critical review of the pros and cons with respect to combining therapy and provides guidelines for its practical use.
Databáze: Directory of Open Access Journals