Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway
Autor: | Lu Li, Fei Liu, Chunyue Feng, Zhenjie Chen, Nan Zhang, Jianhua Mao, Xiangxiang Pan, Peifang Wei |
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Jazyk: | angličtina |
Rok vydání: | 2024 |
Předmět: | |
Zdroj: | Chinese Medical Journal, Vol 137, Iss 9, Pp 1044-1053 (2024) |
Druh dokumentu: | article |
ISSN: | 0366-6999 2542-5641 00000000 |
DOI: | 10.1097/CM9.0000000000003022 |
Popis: | Abstract. Over the past decade, mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease. However, the precise molecular mechanisms linking mitochondrial damage to kidney disease remain elusive. The recent insights into the cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthetase (cGAS)-stimulator of interferon gene (STING) signaling pathway have revealed its involvement in many renal diseases. One of these findings is that mitochondrial DNA (mtDNA) induces inflammatory responses via the cGAS-STING pathway. Herein, we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage, focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney diseases. Furthermore, we summarize the latest findings of cGAS-STING signaling pathway in cell, with a particular emphasis on its downstream signaling related to kidney diseases. This review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway, kidney diseases, and mitochondrial dysfunction. |
Databáze: | Directory of Open Access Journals |
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