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We obtain new controls for the Leray solutions $u$ of the incompressible Navier-Stokes equation in $\mathbb{R}^3$. Specifically, we estimate $u$, $\nabla u$, and $\nabla^2 u$ in suitable Lebesgue spaces $L^{\tilde r}_TL^r$, $r <+ \infty$ with some constraints on $\tilde r>0$. Our method is based on a Duhamel formula around a perturbed heat equation, allowing to thoroughly exploit the well-known energy estimates which balances the potential singularities. We also perform a new Bihari-LaSalle argument in this context. Eventually, we adapt our strategy to prove that $\sup_{t \in [0,T]} \int_{0}^t (t-s)^{-\theta} \|\nabla^k u(s,\cdot)\|_{L^r} ds<+ \infty$, for all $\theta< \frac{3-kr}{2r}$, $k \in [0,2]$, and $1
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