Outan: An On-Head System for Driving micro-LED Arrays Implanted in Freely Moving Mice
| Autor: | Eitan, Alexander Tarnavsky, Someck, Shirly, Zajac, Mario, Socher, Eran, Stark, Eran |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | IEEE Transactions on Biomedical Circuits and Systems, 15:303-13 (2021) |
| Druh dokumentu: | Working Paper |
| DOI: | 10.1109/tbcas.2021.3068556 |
| Popis: | In the intact brain, neural activity can be recorded using sensing electrodes and manipulated using light stimulation. Silicon probes with integrated electrodes and micro-LEDs enable the detection and control of neural activity using a single implanted device. Miniaturized solutions for recordings from small freely moving animals are commercially available, but stimulation is driven by large, stationary current sources. We designed and fabricated a current source chip and integrated it into a headstage PCB that weighs 1.37 g. The proposed system provides 10-bit resolution current control for 32 channels, driving micro-LEDs with up to 4.6 V and sourcing up to 0.9 mA at a refresh rate of 5 kHz per channel. When calibrated against a micro-LED probe, the system allows linear control of light output power, up to 10 micro-W per micro-LED. To demonstrate the capabilities of the system, synthetic sequences of neural spiking activity were produced by driving multiple micro-LEDs implanted in the hippocampal CA1 area of a freely moving mouse. The high spatial, temporal, and amplitude resolution of the system provides a rich variety of stimulation patterns. Combined with commercially available sampling headstages, the system provides an easy to use back-end, fully utilizing the bi-directional potential of integrated opto-electronic arrays. Comment: 11 pages, 9 figures |
| Databáze: | arXiv |
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