Cusp Bifurcation in Metastatic Breast Cancer Cells

Autor:	Delamonica, Brenda, Balazsi, Gabor, Shub, Michael
Rok vydání:	2022
Předmět:	Quantitative Biology - Cell Behavior Mathematics - Dynamical Systems
Druh dokumentu:	Working Paper
Popis:	Ordinary differential equations (ODEs) can model the transition of cell states over time. Bifurcation theory is a branch of dynamical systems which studies changes in the behavior of an ODE system while one or more parameters are varied. We have found that concepts in bifurcation theory may be applied to model metastatic cell behavior. Our results show how a specific phenomenon called a cusp bifurcation describes metastatic cell state transitions, separating two qualitatively different transition modalities. Moreover, we show how the cusp bifurcation models other genetic networks, and we relate the dynamics after the bifurcation to observed phenomena in commitment to enter the cell cycle. Comment: 57 pages, 22 figures, code included
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2203.15888 Zobrazit plný text záznamu View this record from Arxiv