Giga-voxel multidimensional fluorescence imaging combining single-pixel detection and data fusion

Autor: Soldevila, Fernando, Lenz, Armin, Ghezzi, Alberto, Farina, Andrea, D'Andrea, Cosimo, Tajahuerce, Enrique
Rok vydání: 2021
Předmět:
Zdroj: Optics Letters Vol. 46, Issue 17, pp. 4312-4315 (2021)
Druh dokumentu: Working Paper
DOI: 10.1364/OL.434127
Popis: Time-resolved fluorescence imaging is a key tool in biomedical applications, as it allows to non-invasively obtain functional and structural information. However, the big amount of collected data introduces challenges in both acquisition speed and processing needs. Here, we introduce a novel technique that allows to reconstruct a Giga-voxel 4D hypercube in a fast manner while only measuring 0.03 % of the information. The system combines two single-pixel cameras and a conventional 2D array detector working in parallel. Data fusion techniques are introduced to combine the individual 2D and 3D projections acquired by each sensor in the final high-resolution 4D hypercube, which can be used to identify different fluorophore species by their spectral and temporal signatures.
Comment: 6 pages, 4 figures
Databáze: arXiv