Deciphering the underlying mechanisms of the pharyngeal motions in Caenorhabditis elegans
| Autor: | Sherman, Dana, Harel, David |
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| Rok vydání: | 2019 |
| Předmět: | |
| Druh dokumentu: | Working Paper |
| Popis: | The pharynx of the nematode Caenorhabditis elegans is a neuromuscular pump that exhibits two typical motions: pumping and peristalsis. While the dynamics of these motions are well characterized, the underlying mechanisms generating most of them are not known. In this paper, we propose comprehensive and detailed mechanisms that can explain the various observed dynamics of the different pharyngeal areas: the dynamics of the pumping muscles - corpus, anterior isthmus, and terminal bulb - and the peristalsis dynamics of the posterior isthmus muscles. While the suggested mechanisms are consistent with all available relevant data, the assumptions on which they are based and the open questions they raise could point at additional interesting research directions on the C. elegans pharynx. We are hoping that appropriate experiments on the nematode will eventually corroborate our results, and improve our understanding of the functioning of the C. elegans pharynx, and possibly of the mammalian digestive system. Comment: 32 pages, 7 figures |
| Databáze: | arXiv |
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