Nanodiamonds with silicon vacancy defects for non-toxic photostable fluorescent labeling of neural precursor cells

Autor:	Merson, Tobias D., Castelletto, Stefania, Aharonovich, Igor, Turbic, Alisa, Kilpatrick, Trevor J., Turnley, Ann M.
Rok vydání:	2013
Předmět:	Physics - Biological Physics Condensed Matter - Materials Science Quantitative Biology - Biomolecules
Druh dokumentu:	Working Paper
DOI:	10.1364/OL.38.004170
Popis:	Nanodiamonds (NDs) containing silicon vacancy (SiV) defects were evaluated as a potential biomarker for the labeling and fluorescent imaging of neural precursor cells (NPCs). SiV-containing NDs were synthesized using chemical vapor deposition and silicon ion implantation. Spectrally, SiV-containing NDs exhibited extremely stable fluorescence and narrow bandwidth emission with an excellent signal to noise ratio exceeding that of NDs containing nitrogen-vacancy (NV) centers. NPCs labeled with NDs exhibited normal cell viability and proliferative properties consistent with biocompatibility. We conclude that SiVcontaining NDs are a promising biomedical research tool for cellular labeling and optical imaging in stem cell research. Comment: The paper was accepted for publication in Optics letters
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1309.5179 Zobrazit plný text záznamu View this record from Arxiv