KLİNİK ÖRNEKLERİMİZDEN İZOLE EDİLEN STAFİLOKOKLARIN ANTİBİYOTİK DİRENCİ
| Autor: | AYDIN, Neriman, GÜLTEKİN, Berna, EYİGÖR, Mete, GÜREL, Mustafa |
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| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | Volume: 2, Issue: 3 21-26 Meandros Medical And Dental Journal |
| ISSN: | 2149-9063 |
| Popis: | Amaç:Bu çalışmada çeşitli klinik örneklerden izole edilen stafilokokların antibiyotik direncinin saptanması amaçlanmıştır. Yöntem:Çalışmaya, klasik yöntemlerle tanımlanan 274 Staphylococcus. aureus (S. aureus) ve 172 koagülaz negatif stafilokok kökeni alınmıştır. Antibiyotik direnci, penisilin, metisilin, eritromisin, klindamisin, kotrimoksazol, siprofloksasin, vankomisin ve fusidik aside karşı Kirby-Bauer disk difüzyon yöntemi ile araştırılmış, metisilin direncinin saptanmasında oksasilin diski kullanılmıştır. Bulgular:Toplam 274 Staphylococcus aureus kökeninin % 92.3'ü penisiline, %10.9'u metisiline, % 21.5 'i eritromisine, % 14.8'i klindamisine %15.8'i ko-trimoksazole, % 7.3'ü siprofloksasine, % 5.7'si fusidik aside dirençli bulunurken, 172 koagülaz negatif stafilokok kökeninin % 84.2'si penisiline, %38.8'i metisiline, % 54.8'i eritromisine, % 44.4'ü klindamisine, %42.2'si ko-trimoksazole, % 25'i siprofloksasine, % 28.1'i fusidik aside dirençli bulunmuştur. Vankomisin direncine rastlanmamıştır. Sonuç:Koagülaz negatif stafilokok kökenlerinin S. aureusa göre antibiyotiklere daha yüksek oranda dirençli ve tüm stafilokok kökenlerinin vankomisine duyarlı olduğu saptanmıştır Objective:The aim of this study was to detect the antibiotic resistance of staphylococci strains which were isolated from various clinical specimens. Methods:This study included 274 Staphylococcus aureus (S. aureus) and 172 coagulase negative staphylococci strains which were identified with classical methods. Antibiotic resistance of strains to penicilline, methicillin, erythromycin, clindamycin, co-trimoxazole, ciprofloxacin, vancomycin and fucidic acid were investigated by Kirby-Bauer disc diffusion method, while in the detection of methicilline resistance oxacilline discs were used. Results:Among the 274 S. aureus strains, 92.3% were found resistant to penicilline, 10.9% to methicillin, 21.5% to erythromycin 14.8% to clindamycin, 15.8% to co-trimoxazole, 7.3% to ciprofloxacin, 5.7% to fucidic acid. Among 172 CNS strains 84.2% were found resistant to penicilline, 38.8% to methicillin, 54.8% to erythromycin, 44.4% to clindamycin, 42.2% to co-trimoxazole, 25% to ciprofloxacin and 28.1% to fucidic acid. Vancomycin resistance was not detected Conclusion:In this study we found that strains of coagulase negative staphylococci were much more resistant than S. aureus to antibiotics and all staphylococci were susceptible to vancomycin |
| Databáze: | OpenAIRE |
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