| Autor: |
Lilić, Ljubiša M., Toskić, Dragan, Stefanović, Rade Ž., Mekić, Branimir B., Ilić, Ivan R., Stojanović, Nikola M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Acta medica Medianae (2019) 58(2):11-15 |
| ISSN: |
0365-4478 |
| Popis: |
Animal models demonstrating skeletal muscle (SM) disorders are rarely investigated, although these disorders accompany liver disorders and can occur during prolonged exercise/training. It is speculated that mast cells, normally present in the interstitial SM tissue, are involved in the pathophysiology of different SM disorders. Thus, the present study aims to analyze, on the histopathological level, the involvement of mast cells in acute rat intoxication with carbon tetrachloride (CCl4). Biceps and gastrocnemius muscle were obtained from male Wistar rats acutely exposed to CCl4 (1 ml/kg) and the pathological analysis was performed on Toluidine blue stained tissue sections. The obtained results were statically compared with those from a control group using Student's t-test. In SM tissue obtained from the control group mast cells were found only in the interstitium, while in those that received CCl4 they were located mainly near the blood vessels. Also, in the experimental group treated with CCl4 mast cells were more abundant and were in percents more degranulated than those found in the control group. Thus, one can say that the herein presented model of CCl4-induced SM damage is partially dependent on the activity of mast cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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